"Replek" is a company with an 80-year tradition, which over the years has developed and continues to develop in accordance with the needs of its clients and consumers, both in the domestic and foreign markets where it has been present for decades.

As one of the 200 LARGEST AND MOST SUCCESSFUL companies, "Replek" is a leader in its field.

Recognizing the needs of consumers, in accordance with the change in Macedonian legislation, the company was the first to start producing cannabis extract products, or so-called cannabis oil, and offered patients a choice.

It seems that 2016 brought great changes to Macedonian healthcare, when the country for the first time allowed the use of cannabis extract for medical purposes.

That permission largely meant a better and higher quality of life for a large number of citizens who were facing various health problems.

The use of these products in the so-called pain management, i.e. in people who, due to various health conditions, had to live their lives using medications intended for pain relief.

KANOIL® marked a new era in the treatment of oncology patients in North Macedonia

KANOIL® products with different strengths brought a change in Macedonian healthcare and offered a choice to Macedonian patients, who until then, in a state of great pain, had to seek salvation in opioids that created addiction and additional health problems.

KANOIL® oils meant an improvement in the lifestyle, above all of oncology patients, but they also help in the prevention of cardiovascular diseases, i.e. they help in regulating blood pressure, improve heart function, act cardioprotectively and can help in regulating elevated concentrations of lipids and cholesterol in the blood, as well as in regulating elevated concentrations of glucose in the blood.

In addition to helping with conditions of malignant diseases, these oils can also help with multiple sclerosis, HIV and epileptic syndromes in childhood.

The positive effects that these products can have on patients' health were immediately recognized by Macedonian doctors and oncologists, and many of them, along with traditional (chemo)therapy, prescribed KANOIL® oils in order to alleviate the side effects and effects of radiation and chemotherapy to which oncology patients are subjected.

For which health conditions can the products from the KANOIL range be used?

Malignant diseases, Parkinson's disease, Alzheimer's, epileptic seizures, women's health problems...

Replek's cannabis extract products have wide application in modern medicine and can help with various conditions.

Although it is emphasized that they are not a substitute for traditional prescribed therapy, the positive effects of their use have been recognized by a large number of healthcare professionals and organizations around the world, including the American FDA.

What "Replek" offers its clients are products obtained with the highest technology, according to all world standards for this type of product and with guaranteed quality.

KANOIL® oils are extracts from the cannabis or hemp plant, and thanks to the modern technology used in the production of the drug, it has been proven that there are no pesticides and herbicides in the oil extract.

The extraction of the oil is carried out with the most modern technology, i.e. at low temperature without the use of organic solvents, which ensures the highest quality of the oil extract.

"KANOIL® CBD hemp oil may contain cannabinoids, primarily CBD (Cannabidiol), CBN (Cannabinol), CBG (Cannabigerol) and their carboxylic compounds.

Cannabinoids bind to the CB1 and CB2 receptors of the endocannabinoid system and cause an immunomodulatory effect (improves the immune system).

KANOIL® CBD hemp oil may also contain terpenes, omega fatty acids (omega-3, omega-6, omega-9), flavonoids, phytosterols, amino acids, glycosides, vitamins (A, B1, B2, B6, C, D, E, F), pigments, alkanes, nitrogen compounds that are important in cell construction, metabolic processes, maintaining the function of many systems and overall improvement of general health.

KANOIL® CBD hemp oil contains THC (9-delta tetrahydrocannabinol) amounts below 0.2%" - explains Replek.

Similar products from the same range are:

KANOIL® ointment which can:

• have a local anti-inflammatory effect,
• reduce pain and itching,
• affect the secretion of oils from the sebaceous glands (especially in skin with increased secretion of the sebaceous glands in the skin, related to age and hormonal status),
• reduce excessive cell growth (hyperkeratosis).

KANOIL® Gold Nut 25% CBD®

A border product that contains two highly medicinal oils – hemp and walnut.

Walnut oil helps maintain brain (cognitive) functions.

This effect is complemented by the neuroprotective effect of CBD, which improves general health, especially in Parkinson's disease, and contributes to the alleviation of cognitive disorders in Alzheimer's disease.

The combination of the two components in KANOIL® gold nut can have a cardioprotective effect, protect blood vessels, improve heart function, reduce blood pressure, fats and blood sugar, and reduce the risk of diabetes.

KANOIL® femme 50 mg vaginal suppositories contain CBD hemp oil.

The use of KANOIL® femme 50 mg vaginal suppositories has a positive effect on women's intimate health due to the anti-inflammatory effect and positive effect on the immune system of CBD (Cannabidiol).

KANOIL® femme 50 mg pessaries have a beneficial effect on:

• The resistance of the vaginal mucosa to vaginal infections during stress and reduced immunity.
• In vaginal inflammation accompanied by increased secretion.
• In changes in the vaginal mucosa accompanied by itching and pain.
• On improving circulation and epithelialization in damage to the vaginal mucosa.

"Replek" as part of the 200 LARGEST AND MOST SUCCESSFUL

The range of cannabis extract products is further proof of the readiness of "Replek" as a company to constantly keep up with the times and follow all global trends in its field.

Recognized for its quality pharmaceutical products, "Replek" has been synonymous with the production of medicines in North Macedonia according to the highest standards for years.

It is a company that simultaneously follows the trends in pharmacy in all developed European countries.

And hard work gives its results. Proof of this are the positive financial reports, as well as the constant conquest of new markets in the world and the increase in exports.

In 2023, the company generated revenue of 1,652,430,777 MKD, and in one year it recorded a revenue growth of 279.60%.

With a profit growth of 188.63%, "Replek" ranked 177th among the Largest Companies in North Macedonia and 109th among the Most Successful Companies in North Macedonia.

In the same year, the company noted an increase in sales on foreign markets.

Sales outside North Macedonia increased by 43%, and the company's positions were also strengthened on the domestic market, where a growth of 37% was achieved compared to 2022.

Hence, it is clear that in large part the success of "Replek" is due precisely to the change in the export strategy and the increased presence of Macedonian medicines in pharmacies on the foreign market.

"Replek" has been part of the family of 200 LARGEST AND MOST SUCCESSFUL companies in North Macedonia since 2003 and, in accordance with its success, changes positions among the Largest Companies in Macedonia and the Most Successful Companies in Macedonia.

Thanks to the long-term dedicated work, the dedication to the well-being of both its employees and its consumers, from the CLUB 200 publications over the years it can be noted that the company has only been growing.